UniProt functional annotation for O55043



	UniProt functional annotation for O55043

UniProt code: O55043.

Organism: Rattus norvegicus (Rat).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.

Function: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity). {ECO:0000250}.

Subunit: Interacts with SCRIB; interaction is direct and may play a role in regulation of apoptosis (By similarity). Interacts with PAK kinases through the SH3 domain. Interacts with GIT1 and probably TGFB1I1. Interacts with ITCH and PARVB. Interacts with FRMPD4 (via N- terminus). Interacts with CaMK1. Interacts with PTK2/FAK1 and RAC1. Interacts with BIN2 (By similarity). Interacts with YWHAZ (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9ES28}.

Subcellular location: Cell junction, focal adhesion {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=Detected at cell adhesions. A small proportion is detected at focal adhesions.

Ptm: Phosphorylated on Ser-516 by CaMK1; enhancement of GEF activity and downstream activation of RAC1. Phosphorylated by PTK2/FAK1; this promotes interaction with RAC1 (By similarity). {ECO:0000250}.

Annotations taken from UniProtKB at the EBI.


Organism:		Rattus norvegicus (Rat).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.



Function:		Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity). {ECO:0000250}.


Subunit:		Interacts with SCRIB; interaction is direct and may play a role in regulation of apoptosis (By similarity). Interacts with PAK kinases through the SH3 domain. Interacts with GIT1 and probably TGFB1I1. Interacts with ITCH and PARVB. Interacts with FRMPD4 (via N- terminus). Interacts with CaMK1. Interacts with PTK2/FAK1 and RAC1. Interacts with BIN2 (By similarity). Interacts with YWHAZ (By similarity). {ECO:0000250, ECO:0000250\|UniProtKB:Q9ES28}.
Subcellular location:		Cell junction, focal adhesion {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=Detected at cell adhesions. A small proportion is detected at focal adhesions.
Ptm:		Phosphorylated on Ser-516 by CaMK1; enhancement of GEF activity and downstream activation of RAC1. Phosphorylated by PTK2/FAK1; this promotes interaction with RAC1 (By similarity). {ECO:0000250}.