UniProt functional annotation for P49916

UniProt code: P49916.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Function: Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
Catalytic activity: ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).
Cofactor: Magnesium (By similarity).
Subcellular location: Nucleus.
Tissue specificity: Testis, thymus, prostate and heart.
Similarity: Belongs to the ATP-dependent DNA ligase family.
Similarity: Contains 1 BRCT domain.
Similarity: Contains 1 PARP-type zinc finger.
Sequence caution: Sequence=AAA85022.1; Type=Erroneous initiation; Sequence=AAL91592.1; Type=Erroneous initiation; Sequence=CAA59230.1; Type=Erroneous initiation;

Annotations taken from UniProtKB at the EBI.