UniProt functional annotation for Q62446

UniProt code: Q62446.

Organism: Mus musculus (Mouse).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus.
 
Function: FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins (By similarity). {ECO:0000250}.
 
Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0).
Enzyme regulation: Inhibited preferentially by rapamycin over FK506. {ECO:0000250}.
Subcellular location: Nucleus {ECO:0000250}.
Similarity: Belongs to the FKBP-type PPIase family. {ECO:0000305}.
Similarity: Contains 1 PPIase FKBP-type domain. {ECO:0000255|PROSITE-ProRule:PRU00277}.

Annotations taken from UniProtKB at the EBI.