 |
PDBsum entry 3kxh
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Transferase/transferase inhibitor
|
PDB id
|
|
|
|
3kxh
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
References listed in PDB file
|
|
|
Key reference
|
|
|
Title
|
|
Atp site-Directed inhibitors of protein kinase ck2: an update.
|
|
|
Authors
|
|
S.Sarno,
E.Papinutto,
C.Franchin,
J.Bain,
M.Elliott,
F.Meggio,
Z.Kazimierczuk,
A.Orzeszko,
G.Zanotti,
R.Battistutta,
L.A.Pinna.
|
|
|
Ref.
|
|
Curr Top Med Chem, 2011,
11,
1340-1351.
|
|
|
PubMed id
|
|
|
|
|
|
|
|
|
Abstract
|
|
|
No abstract given.
|
|
|
Secondary reference #1
|
|
|
Title
|
|
Structural features underlying selective inhibition of protein kinase ck2 by ATP site-Directed tetrabromo-2-Benzotriazole.
|
|
|
Authors
|
|
R.Battistutta,
E.De moliner,
S.Sarno,
G.Zanotti,
L.A.Pinna.
|
|
|
Ref.
|
|
Protein Sci, 2001,
10,
2200-2206.
[DOI no: ]
|
|
|
PubMed id
|
|
|
|
|
|
|
|
|
|
|
|
Figure 3.
Fig. 3. (A) Two clipped views of the active site showing
the inhibitor (as cpk model) fitting the cavity are shown. The
molecular surface of the protein is represented as a white mesh.
Bromine atoms are in red, carbon atoms in green, and nitrogen
atoms in blue. (B) Position of TBB with respect to that of ATP
(cyan) and emodin (green) in the catalytic site is shown from
different points of view. Inhibitor rings lay practically in the
same plane of the purine moiety of the natural cosubstrates
(bottom).
|
|
|
|
|
|
The above figure is
reproduced from the cited reference
with permission from the Protein Society
|
|
|
Secondary reference #2
|
|
|
Title
|
|
The ATP-Binding site of protein kinase ck2 holds a positive electrostatic area and conserved water molecules.
|
|
|
Authors
|
|
R.Battistutta,
M.Mazzorana,
L.Cendron,
A.Bortolato,
S.Sarno,
Z.Kazimierczuk,
G.Zanotti,
S.Moro,
L.A.Pinna.
|
|
|
Ref.
|
|
Chembiochem, 2007,
8,
1804-1809.
[DOI no: ]
|
|
|
PubMed id
|
|
|
|
|
|
|
|
|
|
|
|
|
