PDBsum entry 3kxh

Transferase/transferase inhibitor

PDB id: 3kxh

Contents

Protein chain

327 a.a. *

Ligands

K66

PEG

Waters ×248

* Residue conservation analysis

PDB id:

3kxh

Name:

Transferase/transferase inhibitor

Title:

Crystal structure of z. Mays ck2 kinase alpha subunit in complex with the inhibitor (2-dymethylammino-4,5,6,7-tetrabromobenzoimidazol-1yl- acetic acid (k66)

Structure:

Casein kinase ii subunit alpha. Chain: a. Fragment: alpha subunit. Synonym: ck2-alpha, ck ii. Engineered: yes

Source:

Zea mays. Maize. Organism_taxid: 4577. Gene: ack2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.70Å R-factor: 0.215 R-free: 0.266

Authors:

E.Papinutto,C.Franchin,R.Battistutta

Key ref:

S.Sarno et al. (2011). ATP site-directed inhibitors of protein kinase CK2: an update. Curr Top Med Chem, 11, 1340-1351. PubMed id: 21513497

Date:

03-Dec-09 Release date: 17-Nov-10

Protein chain

P28523  (CSK2A_MAIZE) -  Casein kinase II subunit alpha from Zea mays

Seq: 332 a.a.

Struc: 327 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

Curr Top Med Chem 11:1340-1351 (2011)

PubMed id: 21513497

ATP site-directed inhibitors of protein kinase CK2: an update.

S.Sarno, E.Papinutto, C.Franchin, J.Bain, M.Elliott, F.Meggio, Z.Kazimierczuk, A.Orzeszko, G.Zanotti, R.Battistutta, L.A.Pinna.

ABSTRACT

No abstract given.