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UniProt functional annotation for P11086 | ||
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| UniProt code: P11086. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Converts noradrenaline to adrenaline. |
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| Catalytic activity: | |
Reaction=phenylethanolamine + S-adenosyl-L-methionine = H(+) + N- methylphenylethanolamine + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:12176, ChEBI:CHEBI:15378, ChEBI:CHEBI:57741, ChEBI:CHEBI:57856, ChEBI:CHEBI:57946, ChEBI:CHEBI:59789; EC=2.1.1.28; |
| Biophysicochemical properties: | |
Kinetic parameters: KM=99 uM for phenylethanolamine {ECO:0000269|PubMed:16363801}; KM=3.4 uM for S-adenosyl-L-methionine {ECO:0000269|PubMed:16363801}; |
| Pathway: | |
Catecholamine biosynthesis; (R)-adrenaline biosynthesis; (R)- adrenaline from (R)-noradrenaline: step 1/1. |
| Similarity: | |
Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.