PDBsum entry 3kmg

Transcription

PDB id: 3kmg

Contents

Protein chains

259 a.a. *

11 a.a. *

18 a.a. *

Ligands

538 ×2

Waters ×204

* Residue conservation analysis

PDB id:

3kmg

Name:

Transcription

Title:

The x-ray crystal structure of ppar-gamma in complex with an indole derivative modulator, gsk538, and an src-1 peptide

Structure:

Peroxisome proliferator-activated receptor gamma. Chain: a, d. Fragment: unp residues 234-505. Synonym: ppar-gamma, nuclear receptor subfamily 1 group c member 3. Engineered: yes. Steroid receptor coactivator-1. Chain: b, e. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: pparg, nr1c3. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide compound

Resolution:

2.10Å R-factor: 0.199 R-free: 0.230

Authors:

R.Gampe

Key ref:

Yann lamotte et al. Synthesis and biological activities of novel indole derivatives as potent and selective ppar-Gamma modulators. To be published, .

Date:

10-Nov-09 Release date: 12-Jan-10

Protein chains

P37231  (PPARG_HUMAN) -  Peroxisome proliferator-activated receptor gamma from Homo sapiens

Seq: 505 a.a.

Struc: 259 a.a.

Protein chain

No UniProt id for this chain

Struc: 11 a.a.

Protein chain

No UniProt id for this chain

Struc: 18 a.a.