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PDBsum entry 3kkt
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Contents |
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* Residue conservation analysis
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PDB id:
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Hydrolase
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Title:
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Crystal structure of human pde4b with 5-[3-[(1s,2s,4r)- bicyclo[2.2.1]hept-2-yloxy]-4-methoxyp henyl]tetrahydro-2(1h)- pyrimidinone reveals ordering of thE C-terminal helix residues 502- 509.
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Structure:
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Camp-specific 3',5'-cyclic phosphodiesterase 4b. Chain: a, b. Fragment: catalytic domain. Synonym: dpde4, pde32. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: dpde4, pde4b. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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2.48Å
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R-factor:
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0.238
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R-free:
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0.295
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Authors:
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R.K.Y.Cheng,L.Crawley,J.Barker,M.Whittaker
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Key ref:
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R.K.Y.Cheng
et al.
Crystal structure of human pde4b with 5-[3-[(1s,2s,4r)-Bicyclo[2.2.1]hept-2-Yloxy]-4- Methoxyp henyl]tetrahydro-2(1h)-Pyrimidinone reveals ordering of the c-Terminal helix residues 502-509..
To be published,
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Date:
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06-Nov-09
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Release date:
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24-Nov-09
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PROCHECK
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Headers
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References
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Q07343
(PDE4B_HUMAN) -
3',5'-cyclic-AMP phosphodiesterase 4B from Homo sapiens
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Seq:
Struc:
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736 a.a.
347 a.a.
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Key: |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.3.1.4.53
- 3',5'-cyclic-AMP phosphodiesterase.
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Reaction:
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3',5'-cyclic AMP + H2O = AMP + H+
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3',5'-cyclic AMP
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+
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H2O
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=
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AMP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
