PDBsum entry 3kka

Transferase

PDB id: 3kka

Contents

Protein chains

64 a.a. *

59 a.a. *

68 a.a. *

Metals

_CL

Waters ×34

* Residue conservation analysis

PDB id:

3kka

Name:

Transferase

Title:

Co-crystal structure of the sam domains of epha1 and epha2

Structure:

Ephrin type-a receptor 1. Chain: a, b. Fragment: sam domain, unp residues 911-974. Synonym: tyrosine-protein kinase receptor eph. Engineered: yes. Ephrin type-a receptor 2. Chain: c, d, e. Fragment: sam domain, unp residues 903-971. Synonym: tyrosine-protein kinase receptor eck, epithelial cell

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: eph, epha1, epht, epht1, mgc163163. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: epha2.

Resolution:

2.40Å R-factor: 0.202 R-free: 0.235

Authors:

J.R.Walker,L.Yermekbayeva,C.Butler-Cole,J.Weigelt,C.Bountra, C.H.Arrowsmith,A.M.Edwards,A.Bochkarev,S.Dhe-Paganon,Structural Genomics Consortium (Sgc)

Key ref:

J.R.Walker et al. Co-Crystal structure of the sam domains of human ephrin type-A receptor 1 and human ephrin type-A receptor 2. To be published, .

Date:

05-Nov-09 Release date: 24-Nov-09

Protein chains

P21709  (EPHA1_HUMAN) -  Ephrin type-A receptor 1 from Homo sapiens

Seq: 976 a.a.

Struc: 64 a.a.

Protein chain

P29317  (EPHA2_HUMAN) -  Ephrin type-A receptor 2 from Homo sapiens

Seq: 976 a.a.

Struc: 59 a.a.

Protein chains

P29317  (EPHA2_HUMAN) -  Ephrin type-A receptor 2 from Homo sapiens

Seq: 976 a.a.

Struc: 68 a.a.

Enzyme reactions

• Enzyme class: Chains A, B, C, D, E: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site