UniProt functional annotation for P15530



	UniProt functional annotation for P15530

UniProt code: P15530.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. {ECO:0000269|PubMed:10352267, ECO:0000269|PubMed:12356683, ECO:0000269|PubMed:15661879, ECO:0000269|PubMed:8175787}.

Subunit: Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts with LYN. {ECO:0000269|PubMed:1506682, ECO:0000269|PubMed:15335855, ECO:0000269|PubMed:20696394, ECO:0000269|PubMed:7592958}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:10587346, ECO:0000269|PubMed:11238609, ECO:0000269|PubMed:15661879}; Single-pass type I membrane protein {ECO:0000269|PubMed:10587346, ECO:0000269|PubMed:11238609, ECO:0000269|PubMed:15661879}. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.

Tissue specificity: B-cells.

Ptm: Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr- kinases such as BLK, LYN and SYK. {ECO:0000269|PubMed:15335855, ECO:0000269|PubMed:7592958}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. {ECO:0000269\|PubMed:10352267, ECO:0000269\|PubMed:12356683, ECO:0000269\|PubMed:15661879, ECO:0000269\|PubMed:8175787}.


Subunit:		Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts with LYN. {ECO:0000269\|PubMed:1506682, ECO:0000269\|PubMed:15335855, ECO:0000269\|PubMed:20696394, ECO:0000269\|PubMed:7592958}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:10587346, ECO:0000269\|PubMed:11238609, ECO:0000269\|PubMed:15661879}; Single-pass type I membrane protein {ECO:0000269\|PubMed:10587346, ECO:0000269\|PubMed:11238609, ECO:0000269\|PubMed:15661879}. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
Tissue specificity:		B-cells.
Ptm:		Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr- kinases such as BLK, LYN and SYK. {ECO:0000269\|PubMed:15335855, ECO:0000269\|PubMed:7592958}.