UniProt functional annotation for P16370

UniProt code: P16370.

Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
 
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft. Seems to be involved in transcription termination.
 
Subunit: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
Subcellular location: Nucleus.
Miscellaneous: Present with 10000 molecules/cell in log phase SD medium.
Similarity: Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family.

Annotations taken from UniProtKB at the EBI.