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UniProt functional annotation for P9WHR9 | ||
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| UniProt code: P9WHR9. |
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| Organism: | |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). |
| Taxonomy: | |
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. |
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| Function: | |
Required for M.tuberculosis resistance to oxidative stress in addition to its role in resistance to acid, which is essential for virulence. It protects M.tuberculosis against phagolysosomal concentrations of acid and maintains its intrabacterial pH when phagocytosed by IFN-gamma-activated macrophages. {ECO:0000269|PubMed:18641659, ECO:0000269|PubMed:20947023}. |
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| Activity regulation: | |
Inhibited by reducing agents and activated during exposure to oxidative stress. {ECO:0000269|PubMed:20947023}. |
| Subunit: | |
Monomer. {ECO:0000269|PubMed:20947023}. |
| Subcellular location: | |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Ptm: | |
Autocleaved. The autocleavage activity is significant only when no reducing agent is present in buffers. |
| Disruption phenotype: | |
Disruption leads to an increased sensitivity to acid and fails to maintain intrabacterial pH in acid in vitro and in activated macrophages. Growth is also severely attenuated in mice. {ECO:0000269|PubMed:18641659}. |
| Miscellaneous: | |
Disulfide bond increases the proteolytic activity by stabilizing the protease in the conformation in which the active site residues are properly positioned for substrate binding and catalysis. |
| Similarity: | |
Belongs to the peptidase S1C family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.