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PDBsum entry 3k4s
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Contents |
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* Residue conservation analysis
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PDB id:
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Hydrolase
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Title:
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The structure of the catalytic domain of human pde4d with 4-(3-butoxy- 4-methoxyphenyl)methyl-2-imidazolidone
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Structure:
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Camp-specific 3',5'-cyclic phosphodiesterase 4d. Chain: a. Fragment: catalytic domain, residues 388-654. Synonym: dpde3, pde43. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d, dpde3. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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2.05Å
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R-factor:
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0.211
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R-free:
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0.262
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Authors:
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L.Crawley,R.K.Y.Cheng,M.Wood,J.Barker,B.Felicetti,M.Whittaker
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Key ref:
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L.Crawley
et al.
The structure of the catalytic domain of human pde4d with 4-(3-Butoxy-4-Methoxyphenyl)methyl-2-Imidazolidone.
To be published,
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Date:
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06-Oct-09
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Release date:
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20-Oct-09
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PROCHECK
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Headers
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References
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Q08499
(PDE4D_HUMAN) -
cAMP-specific 3',5'-cyclic phosphodiesterase 4D from Homo sapiens
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Seq:
Struc:
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809 a.a.
329 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
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Enzyme class:
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E.C.3.1.4.53
- 3',5'-cyclic-AMP phosphodiesterase.
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Reaction:
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3',5'-cyclic AMP + H2O = AMP + H+
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3',5'-cyclic AMP
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+
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H2O
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=
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AMP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
