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PDBsum entry 3k3b
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Motor protein
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PDB id
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3k3b
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References listed in PDB file
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Key reference
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Title
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The discovery of tetrahydro-Beta-Carbolines as inhibitors of the kinesin eg5.
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Authors
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P.A.Barsanti,
W.Wang,
Z.J.Ni,
D.Duhl,
N.Brammeier,
E.Martin,
D.Bussiere,
A.O.Walter.
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Ref.
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Bioorg Med Chem Lett, 2010,
20,
157-160.
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PubMed id
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Abstract
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A series of tetrahydro-beta-carbolines were identified by HTS as inhibitors of
the kinesin Eg5. Molecular modeling and medicinal chemistry techniques were
employed to explore the SAR for this series with a focus of removing potential
metabolic liabilities and improving cellular potency.
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