UniProt functional annotation for P97792



	UniProt functional annotation for P97792

UniProt code: P97792.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3- kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. {ECO:0000269|PubMed:10814828, ECO:0000269|PubMed:20813954, ECO:0000269|PubMed:9036860, ECO:0000269|PubMed:9420240}.

Subunit: Monomer. May form homodimer. Interacts with LNX, MAGI1, DLG4, PRKCABP, TJP1 and CTNNB1. Interacts with MPDZ; recruits MPDZ to intercellular contact sites. Interacts with JAML (homodimeric form). {ECO:0000269|PubMed:20813954, ECO:0000269|PubMed:20813955}.

Subcellular location: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:15533241}; Single-pass type I membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:P78310}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000250|UniProtKB:P78310}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P78310}. Note=In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions. In airway epithelial cells localized to basolateral membrane but not to apical surface. {ECO:0000250|UniProtKB:P78310}.

Subcellular location: [Isoform 3]: Secreted {ECO:0000305}.

Tissue specificity: Expressed in liver, kidney, heart, lung, and brain. In skeletal muscle is found at the neuromuscular junction. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. {ECO:0000269|PubMed:10814828, ECO:0000269|PubMed:12763576, ECO:0000269|PubMed:15533241, ECO:0000269|PubMed:9096397}.

Developmental stage: Expression starts in the embryonic ectoderm in the uterus on 6.5 dpc. Then it is strongly expressed in the neuroepithelium of the neural tube, the developing brain and the spinal cord from 8.5 dpc to postnatal day 7 (P7), in the cranial motor nerves from 9.5 dpc to 11.5 dpc, and in the optic nerve from 13.5 dpc to P7. Expression increases until perinatal period and decreases postnatally. Expressed in the immature neuroepithelium including progenitor cells it still occurs in a few proliferating cells of the hippocampal dentate gyrus, the subventricular zone of the lateral ventricles, and the rostral migratory stream over P21. Also expressed in heart, kidney and liver of newborn mice. {ECO:0000269|PubMed:10814828, ECO:0000269|PubMed:12763576}.

Domain: The Ig-like C2-type 1 domain mediates homodimerization and interaction with JAML. {ECO:0000269|PubMed:20813955}.

Domain: The PDZ-binding motif mediates interaction with MPDZ and MAGI1. {ECO:0000250}.

Ptm: Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane. {ECO:0000250}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3- kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. {ECO:0000269\|PubMed:10814828, ECO:0000269\|PubMed:20813954, ECO:0000269\|PubMed:9036860, ECO:0000269\|PubMed:9420240}.


Subunit:		Monomer. May form homodimer. Interacts with LNX, MAGI1, DLG4, PRKCABP, TJP1 and CTNNB1. Interacts with MPDZ; recruits MPDZ to intercellular contact sites. Interacts with JAML (homodimeric form). {ECO:0000269\|PubMed:20813954, ECO:0000269\|PubMed:20813955}.
Subcellular location:		[Isoform 1]: Cell membrane {ECO:0000269\|PubMed:15533241}; Single-pass type I membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250\|UniProtKB:P78310}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000250\|UniProtKB:P78310}. Cell junction, adherens junction {ECO:0000250\|UniProtKB:P78310}. Note=In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions. In airway epithelial cells localized to basolateral membrane but not to apical surface. {ECO:0000250\|UniProtKB:P78310}.
Subcellular location:		[Isoform 3]: Secreted {ECO:0000305}.
Tissue specificity:		Expressed in liver, kidney, heart, lung, and brain. In skeletal muscle is found at the neuromuscular junction. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. {ECO:0000269\|PubMed:10814828, ECO:0000269\|PubMed:12763576, ECO:0000269\|PubMed:15533241, ECO:0000269\|PubMed:9096397}.
Developmental stage:		Expression starts in the embryonic ectoderm in the uterus on 6.5 dpc. Then it is strongly expressed in the neuroepithelium of the neural tube, the developing brain and the spinal cord from 8.5 dpc to postnatal day 7 (P7), in the cranial motor nerves from 9.5 dpc to 11.5 dpc, and in the optic nerve from 13.5 dpc to P7. Expression increases until perinatal period and decreases postnatally. Expressed in the immature neuroepithelium including progenitor cells it still occurs in a few proliferating cells of the hippocampal dentate gyrus, the subventricular zone of the lateral ventricles, and the rostral migratory stream over P21. Also expressed in heart, kidney and liver of newborn mice. {ECO:0000269\|PubMed:10814828, ECO:0000269\|PubMed:12763576}.
Domain:		The Ig-like C2-type 1 domain mediates homodimerization and interaction with JAML. {ECO:0000269\|PubMed:20813955}.
Domain:		The PDZ-binding motif mediates interaction with MPDZ and MAGI1. {ECO:0000250}.
Ptm:		Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane. {ECO:0000250}.