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PDBsum entry 3jy9
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References listed in PDB file
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Key reference
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Title
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Janus kinase 2 inhibitors. Synthesis and characterization of a novel polycyclic azaindole.
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Authors
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T.Wang,
J.P.Duffy,
J.Wang,
S.Halas,
F.G.Salituro,
A.C.Pierce,
H.J.Zuccola,
J.R.Black,
J.K.Hogan,
S.Jepson,
D.Shlyakter,
S.Mahajan,
Y.Gu,
T.Hoock,
M.Wood,
B.F.Furey,
J.D.Frantz,
L.M.Dauffenbach,
U.A.Germann,
B.Fan,
M.Namchuk,
Y.L.Bennani,
M.W.Ledeboer.
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Ref.
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J Med Chem, 2009,
52,
7938-7941.
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PubMed id
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Abstract
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The synthesis and characterization of a novel polycyclic azaindole based
derivative is disclosed, and its binding to JAK2 is described. The compound is
further evaluated for its ability to block the EPO/JAK2 signaling cascade in
vitro and in vivo.
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