PDBsum entry 3jxt

Signaling protein

PDB id: 3jxt

Contents

Protein chains

96 a.a. *

Ligands

ACE-4DB-ARG-THR-THR-PRO-VAL ×2

ACT

Waters ×340

* Residue conservation analysis

PDB id:

3jxt

Name:

Signaling protein

Title:

Crystal structure of the third pdz domain of sap-102 in complex with a fluorogenic peptide-based ligand

Structure:

Disks large homolog 3. Chain: a, b. Fragment: third pdz domain: unp residues 393-493. Synonym: synapse-associated protein 102, sap102, psd-95/sap90-related protein 1. Engineered: yes. Voltage-dependent calcium channel gamma-2 subunit. Chain: c, d. Fragment: c-terminal motif of stargazin: unp o88602 residues 318-323.

Source:

Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: dlg3, dlgh3. Expressed in: escherichia coli. Expression_system_taxid: 511693. Synthetic: yes. Other_details: peptide ligand obtained by solid phase peptide synthesis

Resolution:

1.50Å R-factor: 0.187 R-free: 0.214

Authors:

M.Sainlos,N.B.Olivier,B.Imperiali

Key ref:

M.Sainlos et al. (2013). Caged mono- and divalent ligands for light-assisted disruption of PDZ domain-mediated interactions. J Am Chem Soc, 135, 4580-4583. PubMed id: 23480637 DOI: 10.1021/ja309870q

Date:

21-Sep-09 Release date: 29-Sep-10

Protein chains

Q62936  (DLG3_RAT) -  Disks large homolog 3 from Rattus norvegicus

Seq: 849 a.a.

Struc: 96 a.a.

DOI no: 10.1021/ja309870q

J Am Chem Soc 135:4580-4583 (2013)

PubMed id: 23480637

Caged mono- and divalent ligands for light-assisted disruption of PDZ domain-mediated interactions.

M.Sainlos, W.S.Iskenderian-Epps, N.B.Olivier, D.Choquet, B.Imperiali.

ABSTRACT

No abstract given.