UniProt functional annotation for P23471

UniProt code: P23471.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
 
Function: Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity).
 
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Subunit: The carbonic-anhydrase like domain interacts with CNTN1 (contactin).
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Secreted (By similarity). Note=A secreted form is apparently generated by shedding of the extracellular domain (By similarity).
Subcellular location: Isoform 2: Secreted (Potential).
Tissue specificity: Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain.
Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
Similarity: Contains 1 alpha-carbonic anhydrase domain.
Similarity: Contains 1 fibronectin type-III domain.
Similarity: Contains 2 tyrosine-protein phosphatase domains.
Sequence caution: Sequence=AAC39934.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. The N-terminus may be contaminated with vector sequence;

Annotations taken from UniProtKB at the EBI.