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PDBsum entry 3jsi
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References listed in PDB file
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Key reference
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Title
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Identification of a brain penetrant pde9a inhibitor utilizing prospective design and chemical enablement as a rapid lead optimization strategy.
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Authors
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P.R.Verhoest,
C.Proulx-Lafrance,
M.Corman,
L.Chenard,
C.J.Helal,
X.Hou,
R.Kleiman,
S.Liu,
E.Marr,
F.S.Menniti,
C.J.Schmidt,
M.Vanase-Frawley,
A.W.Schmidt,
R.D.Williams,
F.R.Nelson,
K.R.Fonseca,
S.Liras.
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Ref.
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J Med Chem, 2009,
52,
7946-7949.
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PubMed id
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Note: In the PDB file this reference is
annotated as "TO BE PUBLISHED". The citation details given above have
been manually determined.
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Abstract
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By use of chemical enablement and prospective design, a novel series of
selective, brain penetrant PDE9A inhibitors have been identified that are
capable of producing in vivo elevations of brain cGMP.
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