UniProt functional annotation for P38249



	UniProt functional annotation for P38249

UniProt code: P38249.

Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).

Taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.

Function: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11387228, ECO:0000269|PubMed:12651896, ECO:0000269|PubMed:18765792, ECO:0000269|PubMed:9694884}.

Subunit: The eukaryotic translation initiation factor 3 (eIF-3) core complex is composed of TIF32, PRT1, NIP1, TIF34 and TIF35. A subcomplex of TIF32, NIP1 and PRT1 mediates the interaction with eIF-1, TIF5/eIF-5 and HCR1. The factors eIF-1, eIF-2, eIF-3, TIF5/eIF-5 and methionyl- tRNAi form a multifactor complex (MFC) that may bind to the 40S ribosome. TIF32, NIP1 and TIF-5/eIF-5 comprise a minimal 40S-ribosome- binding unit. TIF32 interacts with 18S ribosomal RNA and RPS0A. {ECO:0000269|PubMed:12651896, ECO:0000269|PubMed:16581774, ECO:0000269|PubMed:18599441, ECO:0000269|PubMed:9671501, ECO:0000269|PubMed:9694884}.

Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03000}.

Miscellaneous: Present with 52700 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.

Similarity: Belongs to the eIF-3 subunit A family. {ECO:0000255|HAMAP- Rule:MF_03000}.

Annotations taken from UniProtKB at the EBI.


Organism:		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Taxonomy:		Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.



Function:		RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. {ECO:0000255\|HAMAP-Rule:MF_03000, ECO:0000269\|PubMed:11387228, ECO:0000269\|PubMed:12651896, ECO:0000269\|PubMed:18765792, ECO:0000269\|PubMed:9694884}.


Subunit:		The eukaryotic translation initiation factor 3 (eIF-3) core complex is composed of TIF32, PRT1, NIP1, TIF34 and TIF35. A subcomplex of TIF32, NIP1 and PRT1 mediates the interaction with eIF-1, TIF5/eIF-5 and HCR1. The factors eIF-1, eIF-2, eIF-3, TIF5/eIF-5 and methionyl- tRNAi form a multifactor complex (MFC) that may bind to the 40S ribosome. TIF32, NIP1 and TIF-5/eIF-5 comprise a minimal 40S-ribosome- binding unit. TIF32 interacts with 18S ribosomal RNA and RPS0A. {ECO:0000269\|PubMed:12651896, ECO:0000269\|PubMed:16581774, ECO:0000269\|PubMed:18599441, ECO:0000269\|PubMed:9671501, ECO:0000269\|PubMed:9694884}.
Subcellular location:		Cytoplasm {ECO:0000255\|HAMAP-Rule:MF_03000}.
Miscellaneous:		Present with 52700 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity:		Belongs to the eIF-3 subunit A family. {ECO:0000255\|HAMAP- Rule:MF_03000}.