UniProt functional annotation for P25515

UniProt code: P25515.

Organism:		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Taxonomy:		Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
Function:		Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. It is an electrogenic proton pump that generates a proton motive force of 180 mv, inside positive and acidic, in the vacuolar membrane vesicles.
Subunit:		V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d and e). The proteolipid components c, c' and c'' are present as a hexameric ring that forms the proton-conducting pore.
Subcellular location:		Vacuole membrane; Multi-pass membrane protein.
Miscellaneous:		Present with 8450 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity:		Belongs to the V-ATPase proteolipid subunit family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.