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PDBsum entry 3j8f
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Virus/signaling protein
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PDB id
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3j8f
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Contents |
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283 a.a.
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267 a.a.
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235 a.a.
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69 a.a.
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306 a.a.
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PDB id:
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| Name: |
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Virus/signaling protein
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Title:
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Cryo-em reconstruction of poliovirus-receptor complex
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Structure:
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Capsid protein vp1. Chain: 1. Fragment: unp residues 580-881. Synonym: p1d, virion protein 1. Capsid protein vp2. Chain: 2. Fragment: unp residues 70-341. Synonym: p1b, virion protein 2. Capsid protein vp3.
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Source:
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Human poliovirus 1 mahoney. Organism_taxid: 12081. Homo sapiens. Human. Organism_taxid: 9606. Gene: pvr, pvs. Expressed in: escherichia coli. Expression_system_taxid: 562
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Authors:
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M.Strauss,D.J.Filman,D.M.Belnap,N.Cheng,R.T.Noel,J.M.Hogle
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Key ref:
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M.Strauss
et al.
(2015).
Nectin-like interactions between poliovirus and its receptor trigger conformational changes associated with cell entry.
J Virol,
89,
4143-4157.
PubMed id:
DOI:
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Date:
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20-Oct-14
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Release date:
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11-Feb-15
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PROCHECK
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Headers
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References
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P03300
(POLG_POL1M) -
Genome polyprotein from Poliovirus type 1 (strain Mahoney)
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Seq:
Struc:
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2209 a.a.
283 a.a.
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P03300
(POLG_POL1M) -
Genome polyprotein from Poliovirus type 1 (strain Mahoney)
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Seq:
Struc:
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2209 a.a.
267 a.a.
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P03300
(POLG_POL1M) -
Genome polyprotein from Poliovirus type 1 (strain Mahoney)
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Seq:
Struc:
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2209 a.a.
235 a.a.*
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Enzyme class 1:
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Chains 1, 2, 3, 4:
E.C.2.7.7.48
- RNA-directed Rna polymerase.
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Reaction:
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RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate
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RNA(n)
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+
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ribonucleoside 5'-triphosphate
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=
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RNA(n+1)
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+
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diphosphate
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Enzyme class 2:
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Chains 1, 2, 3, 4:
E.C.3.4.22.28
- picornain 3C.
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Reaction:
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Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
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Enzyme class 3:
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Chains 1, 2, 3, 4:
E.C.3.4.22.29
- picornain 2A.
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Reaction:
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Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
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Enzyme class 4:
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Chains 1, 2, 3, 4:
E.C.3.6.1.15
- nucleoside-triphosphate phosphatase.
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Reaction:
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a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H+
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ribonucleoside 5'-triphosphate
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+
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H2O
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=
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ribonucleoside 5'-diphosphate
Bound ligand (Het Group name = )
matches with 45.00% similarity
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+
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phosphate
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+
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H(+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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DOI no:
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J Virol
89:4143-4157
(2015)
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PubMed id:
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Nectin-like interactions between poliovirus and its receptor trigger conformational changes associated with cell entry.
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M.Strauss,
D.J.Filman,
D.M.Belnap,
N.Cheng,
R.T.Noel,
J.M.Hogle.
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ABSTRACT
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