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PDBsum entry 3j8d
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Virus/immune system
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PDB id
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3j8d
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Contents |
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97 a.a.*
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425 a.a.*
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380 a.a.*
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283 a.a.*
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* C-alpha coords only
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PDB id:
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| Name: |
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Virus/immune system
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Title:
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Cryoelectron microscopy of dengue-fab e104 complex at ph 5.5
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Structure:
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Glycoprotein diii. Chain: b, f. Fragment: see remark 999. Engineered: yes. Antibody e111 fab fragment. Chain: a, d. Envelope protein e. Chain: g, h, i. Fragment: unp residues 281-674.
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Source:
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Dengue virus 2 thailand/16681/84. Denv-2. Organism_taxid: 31634. Expressed in: unidentified. Expression_system_taxid: 32644. Mus musculus. Mouse. Organism_taxid: 10090. Expression_system_taxid: 32644
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Authors:
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X.Z.Zhang,J.Sheng,S.K.Austin,T.Hoornweg,J.M.Smit,R.J.Kuhn, M.S.Diamond,M.G.Rossmann
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Key ref:
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X.Zhang
et al.
(2015).
Structure of acidic pH dengue virus showing the fusogenic glycoprotein trimers.
J Virol,
89,
743-750.
PubMed id:
DOI:
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Date:
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13-Oct-14
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Release date:
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12-Nov-14
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Headers
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References
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P17763
(POLG_DEN1W) -
Genome polyprotein from Dengue virus type 1 (strain Nauru/West Pac/1974)
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Seq:
Struc:
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3392 a.a.
97 a.a.
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No UniProt id for this chain
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Enzyme class 1:
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Chains B, F, G, H, I:
E.C.2.1.1.56
- mRNA (guanine-N(7))-methyltransferase.
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Reaction:
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a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L- methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine
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5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA
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+
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S-adenosyl-L- methionine
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=
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5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA
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+
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S-adenosyl-L-homocysteine
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Enzyme class 2:
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Chains B, F, G, H, I:
E.C.2.1.1.57
- methyltransferase cap1.
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Reaction:
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a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)- (2'-O-methyl-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine + H+
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5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA
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+
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S-adenosyl-L-methionine
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=
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5'-end (N(7)-methyl 5'-triphosphoguanosine)- (2'-O-methyl-ribonucleoside) in mRNA
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+
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S-adenosyl-L-homocysteine
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+
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H(+)
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Enzyme class 3:
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Chains B, F, G, H, I:
E.C.2.7.7.48
- RNA-directed Rna polymerase.
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Reaction:
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RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate
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RNA(n)
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+
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ribonucleoside 5'-triphosphate
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=
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RNA(n+1)
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+
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diphosphate
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Enzyme class 4:
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Chains B, F, G, H, I:
E.C.3.4.21.91
- flavivirin.
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Reaction:
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Selective hydrolysis of Xaa-Xaa-|-Xbb bonds in which each of the Xaa can be either Arg or Lys and Xbb can be either Ser or Ala.
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Enzyme class 5:
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Chains B, F, G, H, I:
E.C.3.6.1.15
- nucleoside-triphosphate phosphatase.
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Reaction:
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a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H+
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ribonucleoside 5'-triphosphate
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+
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H2O
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=
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ribonucleoside 5'-diphosphate
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+
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phosphate
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+
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H(+)
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Enzyme class 6:
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Chains B, F, G, H, I:
E.C.3.6.4.13
- Rna helicase.
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Reaction:
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ATP + H2O = ADP + phosphate + H+
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ATP
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+
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H2O
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=
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ADP
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+
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phosphate
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+
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H(+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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DOI no:
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J Virol
89:743-750
(2015)
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PubMed id:
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Structure of acidic pH dengue virus showing the fusogenic glycoprotein trimers.
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X.Zhang,
J.Sheng,
S.K.Austin,
T.E.Hoornweg,
J.M.Smit,
R.J.Kuhn,
M.S.Diamond,
M.G.Rossmann.
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ABSTRACT
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Links
