UniProt functional annotation for P05318

UniProt code: P05318.

Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
 
Function: Plays an important role in the elongation step of protein synthesis.
 
Subunit: Heterodimer of P1A-P2B. Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S). The 5 acidic ribosomal P- proteins form the stalk structure of the 60S subunit. They are organized as a pentameric complex in which P0 interacts with 2 heterodimers, P1A-P2B and P1B-P2A. {ECO:0000269|PubMed:11431471, ECO:0000269|PubMed:16573688, ECO:0000269|PubMed:9559554}.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Ptm: N-terminally acetylated by acetyltransferase NatA. {ECO:0000269|PubMed:10601260, ECO:0000269|PubMed:8476850}.
Miscellaneous: Yeasts contain 4 individual small ribosomal A proteins (RPA) which can be classified into two couples of similar but not identical sequences. Each couple is distinctly related to one of the two A proteins present in multicellular organisms.
Similarity: Belongs to the ribosomal protein L12P family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.