PDBsum entry 3iyp

Virus

PDB id: 3iyp

Contents

Protein chains

277 a.a. *

238 a.a. *

252 a.a. *

61 a.a. *

252 a.a. *

Ligands

DAO

* Residue conservation analysis

PDB id:

3iyp

Name:

Virus

Title:

The interaction of decay-accelerating factor with echovirus 7

Structure:

Capsid protein. Chain: a. Polyprotein. Chain: b. Polyprotein. Chain: c. Polyprotein. Chain: d. Complement decay-accelerating factor.

Source:

Human echovirus 7. Organism_taxid: 46018. Homo sapiens. Human. Organism_taxid: 9606

Authors:

P.Plevka,S.Hafenstein,Y.Zhang,K.G.Harris,J.O.Cifuente,V.D.Bowman, P.R.Chipman,F.Lin,D.E.Medof,C.M.Bator,M.G.Rossmann

Key ref:

P.Plevka et al. (2010). Interaction of decay-accelerating factor with echovirus 7. J Virol, 84, 12665-12674. PubMed id: 20881044

Date:

07-Apr-10 Release date: 24-Nov-10

Protein chain

Q9QP24  (Q9QP24_9ENTO) -  Genome polyprotein (Fragment) from Echovirus E7

Seq: 292 a.a.

Struc: 277 a.a.

Protein chain

Q6W9E5  (Q6W9E5_9ENTO) -  Genome polyprotein from Echovirus E7

Seq: 2194 a.a.

Struc: 238 a.a.

Protein chain

Q6W9E5  (Q6W9E5_9ENTO) -  Genome polyprotein from Echovirus E7

Seq: 2194 a.a.

Struc: 252 a.a.

Protein chain

Q91QV1  (Q91QV1_9ENTO) -  Genome polyprotein (Fragment) from Echovirus E7

Seq: 146 a.a.

Struc: 61 a.a.

Protein chain

P08174  (DAF_HUMAN) -  Complement decay-accelerating factor from Homo sapiens

Seq: 381 a.a.

Struc: 252 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class 1: Chains B, C: E.C.2.7.7.48 - RNA-directed Rna polymerase.
• Reaction: RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate
• Enzyme class 2: Chains B, C: E.C.3.4.22.28 - picornain 3C.
• Reaction: Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
• Enzyme class 3: Chains B, C: E.C.3.4.22.29 - picornain 2A.
• Reaction: Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
• Enzyme class 4: Chains B, C: E.C.3.6.1.15 - nucleoside-triphosphate phosphatase.
• Reaction: a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H⁺

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

J Virol 84:12665-12674 (2010)

PubMed id: 20881044

Interaction of decay-accelerating factor with echovirus 7.

P.Plevka, S.Hafenstein, K.G.Harris, J.O.Cifuente, Y.Zhang, V.D.Bowman, P.R.Chipman, C.M.Bator, F.Lin, M.E.Medof, M.G.Rossmann.

ABSTRACT

No abstract given.