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UniProt functional annotation for P29509 | ||
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| UniProt code: P29509. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Acts on thioredoxins 1 and 2. {ECO:0000269|PubMed:20235561}. |
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| Catalytic activity: | |
Reaction=[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH; Xref=Rhea:RHEA:20345, Rhea:RHEA-COMP:10698, Rhea:RHEA- COMP:10700, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.9; |
| Cofactor: | |
Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000269|PubMed:18930846, ECO:0000269|PubMed:20235561}; Note=Binds 1 FAD per subunit. {ECO:0000269|PubMed:18930846, ECO:0000269|PubMed:20235561}; |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:18930846, ECO:0000269|PubMed:20235561}. |
| Subcellular location: | |
Cytoplasm. Mitochondrion intermembrane space {ECO:0000269|PubMed:22984289}. |
| Miscellaneous: | |
The active site is a redox-active disulfide bond. |
| Miscellaneous: | |
Present with 292000 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.