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PDBsum entry 3it8
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Immune system
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PDB id
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3it8
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Contents |
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(+ 0 more)
152 a.a.
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(+ 0 more)
299 a.a.
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* Residue conservation analysis
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PDB id:
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Immune system
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Title:
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Crystal structure of tnf alpha complexed with a poxvirus mhc-related tnf binding protein
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Structure:
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Tumor necrosis factor. Chain: a, b, c, g, h, i. Fragment: tumor necrosis factor, soluble form, unp residues 82-233. Synonym: tnf-alpha, tumor necrosis factor ligand superfamily member 2, tnf-a, cachectin, tumor necrosis factor, membrane form, tumor necrosis factor, soluble form. Engineered: yes. 2l protein. Chain: d, e, f, j, k, l.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: tnf. Expressed in: escherichia coli. Expression_system_taxid: 562. Yaba-like disease virus. Yldv. Organism_taxid: 132475.
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Resolution:
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2.80Å
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R-factor:
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0.236
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R-free:
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0.266
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Authors:
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Z.Yang,A.P.West Jr.,P.J.Bjorkman
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Key ref:
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Z.Yang
et al.
(2009).
Crystal structure of TNFalpha complexed with a poxvirus MHC-related TNF binding protein.
Nat Struct Biol,
16,
1189-1191.
PubMed id:
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Date:
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27-Aug-09
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Release date:
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20-Oct-09
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PROCHECK
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Headers
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References
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Nat Struct Biol
16:1189-1191
(2009)
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PubMed id:
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Crystal structure of TNFalpha complexed with a poxvirus MHC-related TNF binding protein.
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Z.Yang,
A.P.West,
P.J.Bjorkman.
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ABSTRACT
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The poxvirus 2L protein binds tumor necrosis factor-alpha (TNFalpha) to inhibit
host antiviral and immune responses. The 2.8-A 2L-TNFalpha structure reveals
three symmetrically arranged 2L molecules per TNFalpha trimer. 2L resembles
class I major histocompatibility complex (MHC) molecules but lacks a
peptide-binding groove and beta2-microglobulin light chain. Overlap between the
2L and host TNF receptor-binding sites on TNFalpha rationalizes 2L inhibition of
TNFalpha-TNF receptor interactions and prevention of TNFalpha-induced immune
responses.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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J.Elegheert,
N.Bracke,
P.Pouliot,
I.Gutsche,
A.V.Shkumatov,
N.Tarbouriech,
K.Verstraete,
A.Bekaert,
W.P.Burmeister,
D.I.Svergun,
B.N.Lambrecht,
B.Vergauwen,
and
S.N.Savvides
(2012).
Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1.
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Nat Struct Mol Biol,
19,
938-947.
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PDB codes:
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
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Links
