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PDBsum entry 3i55

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Top Page protein dna_rna ligands metals Protein-protein interface(s) links
Ribosome/antibiotic PDB id
3i55
Jmol
Contents
Protein chains
237 a.a.
337 a.a.
246 a.a.
140 a.a.
172 a.a.
119 a.a.
29 a.a.
160 a.a.
70 a.a.
142 a.a.
132 a.a.
145 a.a.
194 a.a.
186 a.a.
115 a.a.
143 a.a.
95 a.a.
150 a.a.
81 a.a.
119 a.a.
53 a.a.
65 a.a.
154 a.a.
82 a.a.
142 a.a.
73 a.a.
56 a.a.
46 a.a.
92 a.a.
DNA/RNA
Ligands
MYL
Metals
_SR ×108
_NA ×75
_CL ×22
_MG ×93
_CD ×5
__K ×2
Waters ×7823

References listed in PDB file
Key reference
Title Structures of triacetyloleandomycin and mycalamide a bind to the large ribosomal subunit of haloarcula marismortui.
Authors G.Gurel, G.Blaha, T.A.Steitz, P.B.Moore.
Ref. Antimicrob.Agents Chemother., 2009, 53, 5010-5014.
PubMed id 19738021
Abstract
Structures have been obtained for the complexes that triacetyloleandomycin and mycalamide A form with the large ribosomal subunit of Haloarcula marismortui. Triacetyloleandomycin binds in the nascent peptide tunnel and inhibits the activity of ribosomes by blocking the growth of the nascent peptide chain. Mycalamide A binds to the E site and inhibits protein synthesis by occupying the space normally occupied by the CCA end of E-site-bound tRNAs.
PROCHECK
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