PDBsum entry 3i55

Ribosome/antibiotic

PDB id: 3i55

Contents

Protein chains

237 a.a.

337 a.a.

246 a.a.

140 a.a.

172 a.a.

119 a.a.

29 a.a.

160 a.a.

70 a.a.

142 a.a.

132 a.a.

145 a.a.

194 a.a.

186 a.a.

115 a.a.

143 a.a.

95 a.a.

150 a.a.

81 a.a.

119 a.a.

53 a.a.

65 a.a.

154 a.a.

82 a.a.

142 a.a.

73 a.a.

56 a.a.

46 a.a.

92 a.a.

DNA/RNA

Ligands

MYL

Metals

_SR ×108

_NA ×75

_CL ×22

_MG ×93

_CD ×5

__K ×2

Waters ×7823

References listed in PDB file

Key reference

• Title: Structures of triacetyloleandomycin and mycalamide a bind to the large ribosomal subunit of haloarcula marismortui.
• Authors: G.Gürel, G.Blaha, T.A.Steitz, P.B.Moore.
• Ref.: Antimicrob Agents Chemother, 2009, 53, 5010-5014.
• PubMed id: 19738021

Abstract

Structures have been obtained for the complexes that triacetyloleandomycin and mycalamide A form with the large ribosomal subunit of Haloarcula marismortui. Triacetyloleandomycin binds in the nascent peptide tunnel and inhibits the activity of ribosomes by blocking the growth of the nascent peptide chain. Mycalamide A binds to the E site and inhibits protein synthesis by occupying the space normally occupied by the CCA end of E-site-bound tRNAs.