Structures have been obtained for the complexes that triacetyloleandomycin and
mycalamide A form with the large ribosomal subunit of Haloarcula marismortui.
Triacetyloleandomycin binds in the nascent peptide tunnel and inhibits the
activity of ribosomes by blocking the growth of the nascent peptide chain.
Mycalamide A binds to the E site and inhibits protein synthesis by occupying the
space normally occupied by the CCA end of E-site-bound tRNAs.