CNTO4088 is a monoclonal antibody to human IL-23. The X-ray structure of the Fab
fragment revealed an unusual noncanonical conformation of CDR L1. Most
antibodies with the kappa light chain exhibit a canonical structure for CDR L1
in which residue 29 anchors the CDR loop to the framework. Analysis of the
residues believed to define the conformation of CDR L1 did not explain why it
should not adopt a canonical conformation in this antibody. This makes CNTO4088
a benchmark case for developing prediction methods and structure-modeling tools.
