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PDBsum entry 3hzy
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Immune system
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PDB id
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3hzy
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References listed in PDB file
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Key reference
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Title
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Antibodies raised against chlamydial lipopolysaccharide antigens reveal convergence in germline gene usage and differential epitope recognition.
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Authors
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C.L.Brooks,
S.Müller-Loennies,
S.N.Borisova,
L.Brade,
P.Kosma,
T.Hirama,
C.R.Mackenzie,
H.Brade,
S.V.Evans.
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Ref.
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Biochemistry, 2010,
49,
570-581.
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PubMed id
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Abstract
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The structures of antigen-binding fragments from two related monoclonal
antibodies have been determined to high resolution in the presence of several
carbohydrate antigens raised against chlamydial lipopolysaccharide. With the
exception of CDR H3, antibodies S54-10 and S73-2 are both derived from the same
set of germline gene segments as the previously reported structures S25-2 and
S45-18. Despite this similarity, the antibodies differ in specificity and the
mechanism by which they recognize their cognate antigen. S54-10 uses an
unrelated CDR H3 to recognize its antigen in a fashion analogous to S45-18;
however, S73-2 recognizes the same antigen as S45-18 and S54-10 in a wholly
unrelated manner. Together, these antibody-antigen structures provide snapshots
into how the immune system uses the same set of inherited germline gene segments
to generate multiple possible specificities that allow for differential
recognition of epitopes and how unrelated CDR H3 sequences can result in
convergent binding of clinically relevant bacterial antigens.
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