UniProt functional annotation for Q8IWE5



	UniProt functional annotation for Q8IWE5

UniProt code: Q8IWE5.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed:28325809, PubMed:22172677, PubMed:25898167, PubMed:24088571). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Required for maintenance of the Golgi apparatus organization (PubMed:22172677). May play a role in membrane tubulation (PubMed:15905402). {ECO:0000269|PubMed:15905402, ECO:0000269|PubMed:22172677, ECO:0000269|PubMed:24088571, ECO:0000269|PubMed:25898167, ECO:0000269|PubMed:28325809}.

Subunit: Interacts with KLC2 (via TPR repeats) (Probable). Interacts with KIF5B (PubMed:15905402). Interacts with BORCS5 (PubMed:25898167). Interacts (via RUN domain) with ARL8B (GTP-bound form); PLEKHM1 and PLEKHM2 compete for interaction with ARL8B (PubMed:28325809, PubMed:22172677). Interacts with ARL8A (PubMed:28325809). {ECO:0000269|PubMed:15905402, ECO:0000269|PubMed:22172677, ECO:0000269|PubMed:25898167, ECO:0000269|PubMed:28325809, ECO:0000305|PubMed:22172677}.

Subunit: (Microbial infection) Interacts with the S.typhimurium sifA protein; required for S.typhimurium infection. {ECO:0000269|PubMed:15905402, ECO:0000269|PubMed:18996344}.

Subcellular location: Cytoplasm {ECO:0000269|PubMed:15905402}. Lysosome membrane {ECO:0000269|PubMed:22172677}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305|PubMed:22172677}.

Sequence caution: Sequence=AAH40441.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA74865.1; Type=Erroneous initiation; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed:28325809, PubMed:22172677, PubMed:25898167, PubMed:24088571). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Required for maintenance of the Golgi apparatus organization (PubMed:22172677). May play a role in membrane tubulation (PubMed:15905402). {ECO:0000269\|PubMed:15905402, ECO:0000269\|PubMed:22172677, ECO:0000269\|PubMed:24088571, ECO:0000269\|PubMed:25898167, ECO:0000269\|PubMed:28325809}.


Subunit:		Interacts with KLC2 (via TPR repeats) (Probable). Interacts with KIF5B (PubMed:15905402). Interacts with BORCS5 (PubMed:25898167). Interacts (via RUN domain) with ARL8B (GTP-bound form); PLEKHM1 and PLEKHM2 compete for interaction with ARL8B (PubMed:28325809, PubMed:22172677). Interacts with ARL8A (PubMed:28325809). {ECO:0000269\|PubMed:15905402, ECO:0000269\|PubMed:22172677, ECO:0000269\|PubMed:25898167, ECO:0000269\|PubMed:28325809, ECO:0000305\|PubMed:22172677}.
Subunit:		(Microbial infection) Interacts with the S.typhimurium sifA protein; required for S.typhimurium infection. {ECO:0000269\|PubMed:15905402, ECO:0000269\|PubMed:18996344}.
Subcellular location:		Cytoplasm {ECO:0000269\|PubMed:15905402}. Lysosome membrane {ECO:0000269\|PubMed:22172677}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305\|PubMed:22172677}.
Sequence caution:		Sequence=AAH40441.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA74865.1; Type=Erroneous initiation; Evidence={ECO:0000305};