UniProt functional annotation for P27999

UniProt code: P27999.

Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template. Involved in the regulation of transcription elongation. Involved in DNA repair of damage in the transcribed strand. Mediates a transcription-coupled repair (TCR) subpathway of nucleotide excision repair (NER). {ECO:0000269|PubMed:12411509}.
Subunit: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. {ECO:0000269|PubMed:11313498, ECO:0000269|PubMed:11313499, ECO:0000269|PubMed:11805306, ECO:0000269|PubMed:12746495, ECO:0000269|PubMed:12746498, ECO:0000269|PubMed:12914699, ECO:0000269|PubMed:14963322, ECO:0000269|PubMed:15537538, ECO:0000269|PubMed:15591044, ECO:0000269|PubMed:15610738, ECO:0000269|PubMed:16341226, ECO:0000269|PubMed:16765890}.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:P32529}.
Miscellaneous: Present with 2440 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.