PDBsum entry 3hng

Transferase

PDB id: 3hng

Contents

Protein chain

288 a.a. *

Ligands

8ST

Metals

_CL

Waters ×33

* Residue conservation analysis

PDB id:

3hng

Name:

Transferase

Title:

Crystal structure of vegfr1 in complex with n-(4-chlorophenyl)-2- ((pyridin-4-ylmethyl)amino)benzamide

Structure:

Vascular endothelial growth factor receptor 1. Chain: a. Fragment: kinase domain, unp residues 801-1158. Synonym: vegfr-1, vascular permeability factor receptor, tyrosine- protein kinase receptor flt, flt-1, tyrosine-protein kinase frt, fms- like tyrosine kinase 1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: flt1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.70Å R-factor: 0.197 R-free: 0.260

Authors:

L.Tresaugues,A.Roos,C.H.Arrowsmith,H.Berglund,C.Bountra,R.Collins, A.M.Edwards,S.Flodin,A.Flores,S.Graslund,M.Hammarstrom,A.Johansson, I.Johansson,T.Karlberg,T.Kotenyova,M.Moche,T.Nyman,C.Persson, T.Kragh-Nielsen,A.Kotzch,J.Sagemark,H.Schueler,P.Schutz,M.I.Siponen, L.Svensson,A.G.Thorsell,S.Van Der Berg,J.Weigelt,M.Welin, M.Wisniewska,P.Nordlund,Structural Genomics Consortium (Sgc)

Key ref:

L.Tresaugues et al. Crystal structure of vegfr1 in complex with n-(4-Chlorophenyl)-2-((Pyridin-4-Ylmethyl)amino) benzamide. To be published, .

Date:

31-May-09 Release date: 30-Jun-09

Protein chain

P17948  (VGFR1_HUMAN) -  Vascular endothelial growth factor receptor 1 from Homo sapiens

Seq: 1338 a.a.

Struc: 288 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site