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PDBsum entry 3hn4

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protein ligands links
Hormone PDB id
3hn4
Jmol
Contents
Protein chain
256 a.a. *
Ligands
EPE
MPD ×2
SO4 ×2
Waters ×106
* Residue conservation analysis
PDB id:
3hn4
Name: Hormone
Title: Crystal structure of the nk2 fragment (28-289) of human hepa growth factor/scatter factor
Structure: Hepatocyte growth factor. Chain: a. Fragment: unp residues 28-289. Synonym: scatter factor, sf, hepatopoeitin-a, hepatocyte gr factor alpha chain, hepatocyte growth factor beta chain. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hgf, hpta. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.60Å     R-factor:   0.270     R-free:   0.333
Authors: W.D.Tolbert
Key ref: W.D.Tolbert et al. (2010). Structural basis for agonism and antagonism of hepatocyte growth factor. Proc Natl Acad Sci U S A, 107, 13264-13269. PubMed id: 20624990
Date:
29-May-09     Release date:   09-Jun-10    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P14210  (HGF_HUMAN) -  Hepatocyte growth factor
Seq:
Struc:
 
Seq:
Struc:
728 a.a.
256 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 3 residue positions (black crosses)

 

 
Proc Natl Acad Sci U S A 107:13264-13269 (2010)
PubMed id: 20624990  
 
 
Structural basis for agonism and antagonism of hepatocyte growth factor.
W.D.Tolbert, J.Daugherty-Holtrop, E.Gherardi, G.Vande Woude, H.E.Xu.
 
  ABSTRACT  
 
No abstract given.