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PDBsum entry 3hmf

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protein ligands metals links
Transcription PDB id
3hmf

 

 

 

 

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Contents
Protein chain
116 a.a. *
Ligands
EDO
Metals
_CL ×2
_ZN ×2
Waters ×200
* Residue conservation analysis
PDB id:
3hmf
Name: Transcription
Title: Crystal structure of the second bromodomain of human poly-bromodomain containing protein 1 (pb1)
Structure: Protein polybromo-1. Chain: a. Fragment: bromodomain, unp residues 178-291. Synonym: pb1, hpb1, polybromo-1d, brg1-associated factor 180, baf180. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pb1, pbrm1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.63Å     R-factor:   0.172     R-free:   0.199
Authors: P.Filippakopoulos,S.Picaud,T.Keates,J.Muniz,F.Von Delft, C.H.Arrowsmith,A.Edwards,J.Weigelt,C.Bountra,S.Knapp,Structural Genomics Consortium (Sgc)
Key ref: P.Filippakopoulos et al. (2012). Histone recognition and large-scale structural analysis of the human bromodomain family. Cell, 149, 214-231. PubMed id: 22464331
Date:
29-May-09     Release date:   23-Jun-09    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q86U86  (PB1_HUMAN) -  Protein polybromo-1 from Homo sapiens
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1689 a.a.
116 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.?
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

 

 
Cell 149:214-231 (2012)
PubMed id: 22464331  
 
 
Histone recognition and large-scale structural analysis of the human bromodomain family.
P.Filippakopoulos, S.Picaud, M.Mangos, T.Keates, J.P.Lambert, D.Barsyte-Lovejoy, I.Felletar, R.Volkmer, S.Müller, T.Pawson, A.C.Gingras, C.H.Arrowsmith, S.Knapp.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
23211769 C.A.Musselman, M.E.Lalonde, J.Côté, and T.G.Kutateladze (2012).
Perceiving the epigenetic landscape through histone readers.
  Nat Struct Mol Biol, 19, 1218-1227.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.

 

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