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UniProt functional annotation for P19883 | ||
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| UniProt code: P19883. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). |
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| Subunit: | |
Monomer. Isoform 2/FS-288 interacts with GDF11 (PubMed:28257634). {ECO:0000269|PubMed:28257634, ECO:0000305}. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid. {ECO:0000269|PubMed:15472207}. |
Annotations taken from UniProtKB at the EBI.