UniProt functional annotation for Q42521

UniProt code: Q42521.

Organism: Arabidopsis thaliana (Mouse-ear cress).
Taxonomy: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
Function: Catalyzes the production of GABA. The calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis. {ECO:0000269|PubMed:9700069}.
Catalytic activity: L-glutamate = 4-aminobutanoate + CO(2).
Cofactor: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
Enzyme regulation: Up-regulatd by calmodulin binding at physiological pH. {ECO:0000269|PubMed:19580813}.
Biophysicochemical properties: pH dependence: Optimum pH is 6.0. {ECO:0000269|PubMed:19580813};
Subunit: Homohexamer. Interacts with clamodulin with a 1:3 stoichiometry. {ECO:0000269|PubMed:19580813, ECO:0000269|PubMed:7610159, ECO:0000269|PubMed:9700069}.
Tissue specificity: Expressed in roots. Detected at low levels in shoots of young seedlings. Not detected in the root tips or in the central vascular bundle in the elongating region of mature roots. {ECO:0000269|PubMed:15604684, ECO:0000269|PubMed:18077464, ECO:0000269|PubMed:9700069, ECO:0000269|PubMed:9701597}.
Induction: Down-regulated by salt treatment. Not induced by hypoxia. {ECO:0000269|PubMed:18077464, ECO:0000269|PubMed:20122158}.
Domain: The N-terminus (1-57) is involved in the formation of the multimer. The C-terminus (471-502) binds calmodulin in a calcium- dependent fashion and contains probably an autoinhibitory domain.
Disruption phenotype: No visible phenotype, but increased glutamate levels and decreased GABA levels in the roots, and loss of GABA accumulation upon heat stress. {ECO:0000269|PubMed:15604684, ECO:0000269|PubMed:18077464}.
Similarity: Belongs to the group II decarboxylase family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.