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PDBsum entry 3h9o

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protein ligands links
Transferase PDB id
3h9o
Jmol PyMol
Contents
Protein chain
276 a.a. *
Ligands
9BD
Waters ×99
* Residue conservation analysis
PDB id:
3h9o
Name: Transferase
Title: Phosphoinositide-dependent protein kinase 1 (pdk-1) in complex with compound 9
Structure: 3-phosphoinositide-dependent protein kinase 1. Chain: a. Synonym: hpdk1. Ec: 2.7.11.1
Source: Homo sapiens. Human. Organism_taxid: 9606
Resolution:
2.30Å     R-factor:   0.211     R-free:   0.256
Authors: A.M.Olland
Key ref: K.H.Kim et al. (2009). Benzo[c][2,7]naphthyridines as inhibitors of PDK-1. Bioorg Med Chem Lett, 19, 5225-5228. PubMed id: 19628388
Date:
30-Apr-09     Release date:   25-Aug-09    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
O15530  (PDPK1_HUMAN) -  3-phosphoinositide-dependent protein kinase 1
Seq:
Struc:
 
Seq:
Struc:
556 a.a.
276 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.1  - Non-specific serine/threonine protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     protein phosphorylation   1 term 
  Biochemical function     protein kinase activity     2 terms  

 

 
    reference    
 
 
Bioorg Med Chem Lett 19:5225-5228 (2009)
PubMed id: 19628388  
 
 
Benzo[c][2,7]naphthyridines as inhibitors of PDK-1.
K.H.Kim, A.Wissner, M.B.Floyd, H.L.Fraser, Y.D.Wang, R.G.Dushin, Y.Hu, A.Olland, B.Guo, K.Arndt.
 
  ABSTRACT  
 
A series of substituted benzo[c][2,7]-naphthyridines were prepared and showed good potency in inhibiting PDK-1. The synthesis and SAR of this series of compounds are presented as well as the X-ray crystal structure of one of these analogs in a complex with PDK-1.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21754058 K.N.Vennila, K.Prabha, K.J.Prasad, and D.Velmurugan (2011).
7-(4-Meth-oxy-phen-yl)-4,9-dimethyl-N-(4-methyl-phen-yl)-5,12-diaza-tetra-phen-6-amine.
  Acta Crystallogr Sect E Struct Rep Online, 67, o762-o763.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.

 

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