PDBsum entry 3gp2

Metal binding protein/transferase

PDB id: 3gp2

Contents

Protein chains

146 a.a. *

22 a.a. *

Metals

_CA ×4

Waters ×200

* Residue conservation analysis

PDB id:

3gp2

Name:

Metal binding protein/transferase

Title:

Calmodulin bound to peptide from calmodulin kinase ii (camkii)

Structure:

Calmodulin. Chain: a. Synonym: cam. Engineered: yes. Calcium/calmodulin-dependent protein kinase type ii delta chain. Chain: b. Fragment: residues 294-311. Synonym: cam-kinase ii delta chain, cam kinase ii subunit delta,

Source:

Gallus gallus. Chicken. Organism_taxid: 9031. Gene: calm, cam, rcjmb04_24e7. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Homo sapiens. Human.

Resolution:

1.46Å R-factor: 0.161 R-free: 0.192

Authors:

H.L.Ng,T.A.Alber,A.J.Wand

Key ref:

H.L.Ng et al. Calmodulin bound to peptide from calmodulin kinase ii (camkii). To be published, .

Date:

20-Mar-09 Release date: 07-Apr-10

Protein chain

P62149  (CALM_CHICK) -  Calmodulin from Gallus gallus

Seq: 149 a.a.

Struc: 146 a.a.

Protein chain

Q13557  (KCC2D_HUMAN) -  Calcium/calmodulin-dependent protein kinase type II subunit delta from Homo sapiens

Seq: 499 a.a.

Struc: 21 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain B: E.C.2.7.11.17 - calcium/calmodulin-dependent protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺
• Cofactor: Ca(2+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site