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PDBsum entry 3fw3

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Lyase PDB id
3fw3
Jmol
Contents
Protein chain
249 a.a.
Ligands
ETS ×2
GLC
SO4 ×2
Metals
_ZN ×2
Waters ×264

References listed in PDB file
Key reference
Title Thioether benzenesulfonamide inhibitors of carbonic anhydrases ii and IV: structure-Based drug design, Synthesis, And biological evaluation.
Authors W.F.Vernier, K.M chong, D.A.Rewolinski, S.E.Greasley, T.A.Pauly, M.Cobbs, D.M.Dinh, R.A.A.Ferre, S.Nukui, M.A.Ornelas, E.L.Reyner.
Ref. Bioorg.Med.Chem., 2010, 18, 3307-3319. [DOI no: 10.1016/j.bmc.2010.03.014]
PubMed id 20363633
Abstract
A novel series of potent thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV was discovered using structure-based drug design. Synthesis, structure-activity relationship, and optimization of physicochemical properties are described. Low nanomolar potency was achieved, and selected compounds with improved thermodynamic solubility showed promising in vitro inhibition of carbonic anhydrase activity in rabbit iris ciliary body homogenate.
PROCHECK
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 Headers