 |
PDBsum entry 3fv8
|
|
|
|
References listed in PDB file
|
 |
|
Key reference
|
|
|
Title
|
|
Synthesis and sar of piperazine amides as novel c-Jun n-Terminal kinase (jnk) inhibitors.
|
|
|
Authors
|
|
Y.Shin,
W.Chen,
J.Habel,
D.Duckett,
Y.Y.Ling,
M.Koenig,
Y.He,
T.Vojkovsky,
P.Lograsso,
T.M.Kamenecka.
|
|
|
Ref.
|
|
Bioorg Med Chem Lett, 2009,
19,
3344-3347.
|
|
|
PubMed id
|
|
|
|
|
|
Abstract
|
|
|
A novel series of c-jun N-terminal kinase (JNK) inhibitors were designed and
developed from a high-throughput-screening hit. Through the optimization of the
piperazine amide 1, several potent compounds were discovered. The X-ray crystal
structure of 4g showed a unique binding mode different from other well known
JNK3 inhibitors.
|
|
|
|
|
|
|
