 |
PDBsum entry 3fpm
|
|
|
|
References listed in PDB file
|
 |
|
Key reference
|
|
|
Title
|
|
Identification and sar of squarate inhibitors of mitogen activated protein kinase-Activated protein kinase 2 (mk-2).
|
|
|
Authors
|
|
F.Lovering,
S.Kirincich,
W.Wang,
K.Combs,
L.Resnick,
J.E.Sabalski,
J.Butera,
J.Liu,
K.Parris,
J.B.Telliez.
|
|
|
Ref.
|
|
Bioorg Med Chem Lett, 2009,
17,
3342-3351.
|
|
|
PubMed id
|
|
|
|
|
|
Abstract
|
|
|
A novel series of inhibitors for mitogen activated protein kinase-activated
protein kinase 2 (MK-2) are reported. These squarate based inhibitors were
identified via a high-throughput screen. An MK2 co-structure with the starting
ligand was obtained and a structure based approach was followed to optimize
potency and selectivity.
|
|
|
|
|
|
|
