PDBsum entry 3fmn

Signaling protein, transferase

PDB id: 3fmn

Contents

Protein chain

341 a.a. *

Ligands

530

Waters ×370

* Residue conservation analysis

PDB id:

3fmn

Name:

Signaling protein, transferase

Title:

P38 kinase crystal structure in complex with ro2530

Structure:

Mitogen-activated protein kinase 14. Chain: a. Synonym: mitogen-activated protein kinase p38 alpha, map kinase p38 alpha, cytokine suppressive anti-inflammatory drug-binding protein, csaid-binding protein, csbp, max-interacting protein 2, map kinase mxi2, sapk2a. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: csbp, csbp1, csbp2, cspb1, mapk14, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.90Å R-factor: 0.206 R-free: 0.242

Authors:

A.Kuglstatter,M.Ghate

Key ref:

M.Soth et al. P38 kinase crystal structure in complex with ro2530. To be published, .

Date:

22-Dec-08 Release date: 22-Dec-09

Protein chain

Q16539  (MK14_HUMAN) -  Mitogen-activated protein kinase 14 from Homo sapiens

Seq: 360 a.a.

Struc: 341 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.24 - mitogen-activated protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site