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UniProt functional annotation for O75689 | ||
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| UniProt code: O75689. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). {ECO:0000269|PubMed:10448098, ECO:0000303|PubMed:10333475, ECO:0000305}. |
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| Subunit: | |
Interacts with PRKCA, PRKCI and PRKCZ. Interacts with the N- terminal region of PRKD1. {ECO:0000269|PubMed:12893243}. |
| Subcellular location: | |
Nucleus. Cytoplasm. Note=Recruited to the plasma membrane upon epidermal growth factor-dependent activation of phosphatidylinositol 4,5-diphosphate (PtdInsP2) 3-kinase. |
| Tissue specificity: | |
Expressed at highest levels in brain and at lower levels in peripheral blood leukocytes. {ECO:0000269|PubMed:10448098}. |
| Ptm: | |
Phosphorylated by PRKCA, PRKCI, PRKCZ and PRKD1 in vitro. {ECO:0000269|PubMed:12893243}. |
Annotations taken from UniProtKB at the EBI.