UniProt functional annotation for Q9Y259

UniProt code: Q9Y259.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
 
Function: Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis.
 
Catalytic activity: ATP + choline = ADP + phosphocholine.
Catalytic activity: ATP + ethanolamine = ADP + O- phosphoethanolamine.
Biophysicochemical properties: Kinetic parameters: KM=0.57 mM for choline; KM=2.9 mM for ethanolamine;
Pathway: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.
Subunit: Homodimer, and heterodimer with CHKA.
Miscellaneous: This protein is produced by a bicistronic gene which also produces the CPT1B protein from a non-overlapping reading frame.
Similarity: Belongs to the choline/ethanolamine kinase family.
Sequence caution: Sequence=AAB03342.2; Type=Erroneous gene model prediction;

Annotations taken from UniProtKB at the EBI.