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PDBsum entry 3fe4

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Lyase PDB id
3fe4
Jmol
Contents
Protein chain
244 a.a.
Ligands
GOL ×2
Metals
_MG ×2
Waters ×429

References listed in PDB file
Key reference
Title Crystal structure of the secretory isozyme of mammalian carbonic anhydrases ca VI: implications for biological assembly and inhibitor development.
Authors E.S.Pilka, G.Kochan, U.Oppermann, W.W.Yue.
Ref. Biochem Biophys Res Commun, 2012, 419, 485-489.
PubMed id 22366092
Abstract
Zn(2+)-dependent carbonic anhydrases (CA) catalyse the reversible hydration of carbon dioxide to bicarbonate and participate in diverse physiological processes, hence having manifold therapeutic potentials. Among the 15 human CAs with wide-ranging sub-cellular localisation and kinetic properties, CA VI is the only secretory isoform. The 1.9Å crystal structure of the human CA VI catalytic domain reveals a prototypical mammalian CA fold, and a novel dimeric arrangement as compared to previously-reported CA structures. The active site cavity contains a cluster of non-conserved residues that may be involved in ligand binding and have significant implications for developing the next-generation of isoform-specific inhibitors.
PROCHECK
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 Headers