UniProt functional annotation for P33242



	UniProt functional annotation for P33242

UniProt code: P33242.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (By similarity). Transcription repressor of the Moloney leukemia virus long terminal repeat in undifferentiated murine embryonal carcinoma cells. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular phosphatidyl(3,4)bisphosphate, phosphatidyl(3,5)bisphosphate and phosphatidyl(3,4,5)triphosphate. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. {ECO:0000250, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:18988706}.

Subunit: Binds DNA as a monomer (By similarity). Part of a complex consisting of SFPQ, NONO and NR5A1. Interacts with DGKQ and CDK7 (By similarity). Interacts with NR0B2, NCOA2 and PPARGC1A. Binds to and activated by HIPK3. {ECO:0000250, ECO:0000269|PubMed:15707893, ECO:0000269|PubMed:15721253, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:18988706, ECO:0000269|PubMed:8395013}.

Subcellular location: Nucleus.

Developmental stage: Expressed during early embryonic development. Expressed only in undifferentiated embryonal carcinoma cells.

Ptm: Acetylation stimulates the transcriptional activity. {ECO:0000250}.

Ptm: Sumoylation reduces CDK7-mediated phosphorylation on Ser-203. {ECO:0000250}.

Ptm: Phosphorylated on Ser-203 by CDK7. This phosphorylation promotes transcriptional activity (By similarity). {ECO:0000250}.

Similarity: Belongs to the nuclear hormone receptor family. NR5 subfamily. {ECO:0000305}.

Sequence caution: Sequence=BAA01441.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (By similarity). Transcription repressor of the Moloney leukemia virus long terminal repeat in undifferentiated murine embryonal carcinoma cells. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular phosphatidyl(3,4)bisphosphate, phosphatidyl(3,5)bisphosphate and phosphatidyl(3,4,5)triphosphate. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. {ECO:0000250, ECO:0000269\|PubMed:17210646, ECO:0000269\|PubMed:18988706}.


Subunit:		Binds DNA as a monomer (By similarity). Part of a complex consisting of SFPQ, NONO and NR5A1. Interacts with DGKQ and CDK7 (By similarity). Interacts with NR0B2, NCOA2 and PPARGC1A. Binds to and activated by HIPK3. {ECO:0000250, ECO:0000269\|PubMed:15707893, ECO:0000269\|PubMed:15721253, ECO:0000269\|PubMed:17210646, ECO:0000269\|PubMed:18988706, ECO:0000269\|PubMed:8395013}.
Subcellular location:		Nucleus.
Developmental stage:		Expressed during early embryonic development. Expressed only in undifferentiated embryonal carcinoma cells.
Ptm:		Acetylation stimulates the transcriptional activity. {ECO:0000250}.
Ptm:		Sumoylation reduces CDK7-mediated phosphorylation on Ser-203. {ECO:0000250}.
Ptm:		Phosphorylated on Ser-203 by CDK7. This phosphorylation promotes transcriptional activity (By similarity). {ECO:0000250}.
Similarity:		Belongs to the nuclear hormone receptor family. NR5 subfamily. {ECO:0000305}.
Sequence caution:		Sequence=BAA01441.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};