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PDBsum entry 3f66
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protein ligands metals Protein-protein interface(s) links
Transferase PDB id
3f66

 

 

 

 

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JSmol PyMol  
Contents
Protein chains
288 a.a. *
269 a.a. *
Ligands
IHX ×2
GBL ×5
Metals
_NA
Waters ×453
* Residue conservation analysis
PDB id:
3f66
Name: Transferase
Title: Human c-met kinase in complex with quinoxaline inhibitor
Structure: Hepatocyte growth factor receptor. Chain: a, b. Fragment: unp residues 1052-1349. Synonym: hgf receptor, scatter factor receptor, sf receptor, hgf/sf receptor, met proto-oncogene tyrosine kinase, c-met. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Resolution:
1.40Å     R-factor:   0.168     R-free:   0.225
Authors: C.Meier,T.Ceska
Key ref: J.Porter et al. (2009). Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase. Bioorg Med Chem Lett, 19, 397-400. PubMed id: 19059779
Date:
05-Nov-08     Release date:   23-Dec-08    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P08581  (MET_HUMAN) -  Hepatocyte growth factor receptor from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1390 a.a.
288 a.a.
Protein chain
Pfam   ArchSchema ?
P08581  (MET_HUMAN) -  Hepatocyte growth factor receptor from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1390 a.a.
269 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains A, B: E.C.2.7.10.1  - receptor protein-tyrosine kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
L-tyrosyl-[protein]
 + ATP
 = O-phospho-L-tyrosyl-[protein]
 + ADP
 + H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    Added reference    
 
 
Bioorg Med Chem Lett 19:397-400 (2009)
PubMed id: 19059779  
 
 
Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase.
J.Porter, S.Lumb, F.Lecomte, J.Reuberson, A.Foley, M.Calmiano, K.le Riche, H.Edwards, J.Delgado, R.J.Franklin, J.M.Gascon-Simorte, A.Maloney, C.Meier, M.Batchelor.
 
  ABSTRACT  
 
A series of quinoxaline inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and optimisation of the series was performed on the basis of this structure. Future directions for development of the series are discussed together with the identification of a novel quinoline scaffold.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21487786 J.Caballero, M.Quiliano, J.H.Alzate-Morales, M.Zimic, and E.Deharo (2011).
Docking and quantitative structure-activity relationship studies for 3-fluoro-4-(pyrrolo[2,1-f][1,2,4]triazin-4-yloxy)aniline, 3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline, and 4-(4-amino-2-fluorophenoxy)-2-pyridinylamine derivatives as c-Met kinase inhibitors.
  J Comput Aided Mol Des, 25, 349-369.  
21478016 L.You, E.J.Cho, J.Leavitt, L.C.Ma, G.T.Montelione, E.V.Anslyn, R.M.Krug, A.Ellington, and J.D.Robertus (2011).
Synthesis and evaluation of quinoxaline derivatives as potential influenza NS1A protein inhibitors.
  Bioorg Med Chem Lett, 21, 3007-3011.  
21561768 Z.Liang, D.Zhang, J.Ai, L.Chen, H.Wang, X.Kong, M.Zheng, H.Liu, C.Luo, M.Geng, H.Jiang, and K.Chen (2011).
Identification and synthesis of N'-(2-oxoindolin-3-ylidene)hydrazide derivatives against c-Met kinase.
  Bioorg Med Chem Lett, 21, 3749-3754.  
19446547 G.Marverti, A.Ligabue, G.Paglietti, P.Corona, S.Piras, G.Vitale, D.Guerrieri, R.Luciani, M.P.Costi, C.Frassineti, and M.S.Moruzzi (2009).
Collateral sensitivity to novel thymidylate synthase inhibitors correlates with folate cycle enzymes impairment in cisplatin-resistant human ovarian cancer cells.
  Eur J Pharmacol, 615, 17-26.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.

 

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