UniProt functional annotation for P53615

UniProt code: P53615.

Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
Function: Catalyzes the reversible hydration of CO(2) to H(2)CO(3). The main role may be to provide inorganic carbon for the bicarbonate-dependent carboxylation reactions catalyzed by pyruvate carboxylase, acetyl-CoA carboxylase and carbamoyl- phosphate synthetase. Involved in protection against oxidative damage. Encodes a substrate for the non-classical protein export pathway for proteins that lack a cleavable signal sequence.
Catalytic activity: H(2)CO(3) = CO(2) + H(2)O.
Cofactor: Binds 1 zinc ion per subunit (By similarity).
Biophysicochemical properties: Kinetic parameters: Note=kcat is 940000 sec(-1) with CO(2) as substrate;
Subcellular location: Cytoplasm. Nucleus. Mitochondrion intermembrane space.
Induction: Transcription and activity down-regulated at elevated CO(2) concentrations.
Miscellaneous: Present with 2330 molecules/cell in log phase SD medium.
Similarity: Belongs to the beta-class carbonic anhydrase family.

Annotations taken from UniProtKB at the EBI.