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PDBsum entry 3eta
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Signaling protein, transferase
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PDB id
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3eta
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References listed in PDB file
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Key reference
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Title
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Discovery of 3,5-Disubstituted-1h-Pyrrolo[2,3-B]pyridines as potent inhibitors of the insulin-Like growth factor-1 receptor (igf-1r) tyrosine kinase.
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Authors
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S.Patnaik,
K.L.Stevens,
R.Gerding,
F.Deanda,
J.B.Shotwell,
J.Tang,
T.Hamajima,
H.Nakamura,
M.A.Leesnitzer,
A.M.Hassell,
L.M.Shewchuck,
R.Kumar,
H.Lei,
S.D.Chamberlain.
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Ref.
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Bioorg Med Chem Lett, 2009,
19,
3136-3140.
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PubMed id
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Abstract
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Exploration of the SAR around a series of
3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines led to the discovery of novel
pyrrolopyridine inhibitors of the IGF-1R tyrosine kinase. Several compounds
demonstrated nanomolar potency in enzyme and cellular mechanistic assays.
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